NDLI: Toward the application of raman fiber probe for non invasive cancer diagnosis

Content Provider	IEEE Xplore Digital Library
Author	Bintang, A.B. Sato, H. Miyoshi, N.
Copyright Year	2012
Description	Author affiliation: Department of Etiologic and Pathologic Medicine, University of Fukui, Eiheiji-cho Yoshida-gun, 910-1193, Japan (Miyoshi, N.) \|\| School of Science and Technology, Kwansei Gakuin University, Gakuen, Sanda 669-1337, Japan (Bintang, A.B.; Sato, H.)
Abstract	Ball-lens hollow Raman Probe (BHRP) and FTIR spectroscopy were used in this study. BHRP was purposed to explore the biochemical alteration in the living animal (in vivo study), mean while FTIR spectroscopy was introduced for clarification of BHRP result. In this study, we focused to the alteration of antisymmetric and symmetric P=O stretching vibration within the azoxymethane-induced colorectal tumor (in mouse). BHRP detected some differences of it due to randomly the edge of BHRP attached the surface of tumor. Meanwhile, the application of FTIR were introduced to differentiate between grade levels of non clinic samples colorectal tumor models at 4 different grades; normal, grade 1, grade2 and grade 3. Detailed investigation of the spectra in the fingerprint region 1800–700 $cm^{−1}$ for BHRP and 4000–500 $cm^{−1}$ for FTIR revealed some distinct peaks and shoulders, most of which were assignable to wave numbers that shown to represent biochemical changing within the tissue. Differences in peak heights and peak ratios indicated differences in biochemical composition of cancer from different grade level. It was possible to distinguish between their grade. However, all collected colorectal tumor model at different peak was distinguishable, where antisymmetric stretching of CH2, antisymmetric and symmetric P=O stretching vibration was imaged and mapped clearly. Therefore, BHRP collaborated with FTIR spectral analysis and in combination with calibration curve might be used to distinguish cancer grade within colorectal tumor model tissue. Extension of this method to other cancer type may be of great interest for cancer grade determination.
Starting Page	157
Ending Page	159
File Size	149689
Page Count	3
File Format	PDF
ISBN	9781457721724
e-ISBN	9781457721717
DOI	10.1109/GUT.2012.6344173
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-07-07
Publisher Place	Indonesia
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Vibrations Spectroscopy Raman scattering Imaging Raman fiber probe Mice Colorectal tumor Tumors Cancer
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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