NDLI: A comparison of three weighted human gene functional association networks

Content Provider	IEEE Xplore Digital Library
Author	Jing Zhao Chun-Lin Wang Ting-Hong Yang Bo Li Xing Chen Xiaona Shen Ling Fang
Copyright Year	2012
Description	Author affiliation: Department of Mathematics, Logistical Engineering University, Chongqing, China (Jing Zhao; Chun-Lin Wang; Ting-Hong Yang; Bo Li; Xing Chen; Xiaona Shen; Ling Fang)
Abstract	Gene-gene association or protein-protein interaction databases have been important resource for the study of cellular functions and human diseases. A number of gene association databases have been available in the public domain. Each of these databases has its own unique virtues, but no single database could provide enough confidence and coverage. These years some meta-databases have been built by integrating various resources of gene functional associations and weighing the evidence of each association by some score systems. In this work, we compared three weighted genome-scale human gene association networks constructed from three such meta-databases, STRING, FunCoup and FLN, respectively. We found that the three networks share a large fraction of common genes but only quite limited overlapped interactions. However, most genes involved in important cellular processes and human diseases, as well as their pairwise interactions, is included in all of the three networks. This explains why all the three networks have been successfully applied in the study of cellular functions and diseases mechanisms. We believe that further integration of these meta-databases would provide higher confidence and coverage of gene associations in human proteome and facilitate the study of human gene association networks.
Starting Page	26
Ending Page	31
File Size	656868
Page Count	6
File Format	PDF
ISBN	9781467343961
e-ISBN	9781467343985
e-ISBN	9781467343978
DOI	10.1109/ISB.2012.6314108
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-08-18
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Confidence score Protein complex Databases Humans Genomics Gene-association network Pathway Disease-related gene Bioinformatics Diseases Immune system
Content Type	Text
Resource Type	Article

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