NDLI: Antiallodynic effects of microglial interleukin-1β inhibition in the spinal cord

Content Provider	IEEE Xplore Digital Library
Author	Yu-Xia Chu Min Wang Ming Yao Xin-Mei Zhou Xia-Ying Du Xiao Wan Zi-Fang Li Meng-Jia Zhu Xiao Chen
Copyright Year	2011
Description	Author affiliation: Department of Physiology College of Medicine, Jiaxing University, China (Yu-Xia Chu; Min Wang; Ming Yao; Xin-Mei Zhou; Xia-Ying Du; Xiao Wan; Zi-Fang Li; Meng-Jia Zhu; Xiao Chen)
Abstract	Microglia play a pivotal role in synaptic plasticity of chronic pain. In this study, the potential role of interleukin 1beta (IL-1β), mainly released by microglia in early stage of nerve injury, in mechanical allodynia induced by tetanic stimulation of the sciatic nerve (TSS) was examined. Mechanical allodynia was observed on both ipsilateral and contralateral sides of TSS. Moreover, the expression of the microglial marker Iba-1 and the proinflammatory cytokine IL-1β were significantly increased. Intrathecal injection of the IL-1 receptor antagonist (IL-1ra, 3.5 µg/ml, 20 µl/rat) 30 min before TSS significantly inhibited bilateral mechanical allodynia on day 3, 5 and 7 after TSS. Immunohistochemistry showed that IL-1β was colocalized with the microglial marker OX-42 in the spinal superficial dorsal horn, but not with the astrocytic marker GFAP and the neuronal marker NeuN on day 4 following TSS. The results demonstrate that microglial IL-1β participates in the hypersensitivity of pain behaviors induced by TSS.
Starting Page	133
Ending Page	136
File Size	670471
Page Count	4
File Format	PDF
ISBN	9781457716614
e-ISBN	9781457716669
e-ISBN	9781457716652
DOI	10.1109/ISB.2011.6033144
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-09-02
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Allodynia Spinal cord Pain Conferences Systems biology Rats Interleukin 1beta Immune system Microglia
Content Type	Text
Resource Type	Article

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