NDLI: Combination of Multiple Distance Measures for Protein Fold Classification

Content Provider	IEEE Xplore Digital Library
Author	Suryanto, C.H. Hino, H. Fukui, K.
Copyright Year	2013
Description	Author affiliation: Grad. Sch. of Syst. & Inf. Eng., Univ. of Tsukuba, Tsukuba, Japan (Suryanto, C.H.; Hino, H.; Fukui, K.)
Abstract	In structural biology, measuring the similarity between two protein structures is an essential task. The most common approach is to find the best alignment between two protein backbone structures and use the root mean square deviation (RMSD) of the superimposed alpha-carbon atom coordinates as the distance measurement. Other approaches extract features of the protein structures and the similarity measure is based on the extracted features. However, there is no single best approach, as each has its own advantages and limitations. One intuitive idea is that a better result can be obtained by combining complementary approaches. In this paper, we propose a new approach to protein fold classification, by introducing the concept of large margin nearest neighbor for combining multiple measures of distance between protein structures. We combine the Euclidean distance matrices of 12 features extracted from the amino acid sequence of the protein, the RMSD obtained from the geometrical alignment using Combinatorial Extension, and the canonical angles between the subspaces generated from the synthesized multi-view protein structure images. We demonstrate the effectiveness of the proposed method by classifying 27 fold classes of proteins in the Ding Dubchak dataset.
Starting Page	440
Ending Page	445
File Size	355328
Page Count	6
File Format	PDF
ISBN	9781479921904
DOI	10.1109/ACPR.2013.139
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-11-05
Publisher Place	Japan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Measurement Training Three-dimensional displays Accuracy Feature extraction Protein fold classification Vectors Metric learning Large margin nearest neighbor
Content Type	Text
Resource Type	Article

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