NDLI: Role of TLR4 and IL1A polymorphisms in Generalized Aggressive Periodontitis in a Romanian population

Content Provider	IEEE Xplore Digital Library
Author	Barnea, T.V. Costuleanu, M.
Copyright Year	2013
Description	Author affiliation: Dept. of Gen. & Oro-Maxillo-Facial Pathology, Univ. of Med. & Pharmacy UMF Grigore T. Popa, Iasi, Romania (Barnea, T.V.; Costuleanu, M.)
Abstract	We aimed to assess an association of some genotypes with Generalized Aggressive Periodontitis susceptibility by studying functional relevant variants in the pathogen-recognition receptor Toll-like receptor 4 and variants in the promoter region of the proinflammatory cytokine interleukin-1alpha in a sample of Romanian individuals. Forty-four Romanian patients with Generalized Aggressive Periodontitis and twenty-one healthy from periodontal point of view were genotyped for three single nucleotide polymorphisms of Tolllike receptor 4 (TLR4 Asp299Gly and TLR4 Thr399Ile) and interleukin-1alpha (IL1A(-889))using Real-Time PCR and saliva samples. There were no statistical differences in genotype distribution within the three variants, between the cases and controls group. We performed Fisher's exact test and chi square test for assessing the genotype and allelic distribution. Our results reject the hypothesis that functionally polymorphisms of Toll-like receptor 4 and interleukin-1alpha genes have a major effect on Generalized Aggressive Periodontitis susceptibility, alone or in combination.
Starting Page	1
Ending Page	4
File Size	239381
Page Count	4
File Format	PDF
e-ISBN	9781479923731
DOI	10.1109/EHB.2013.6707321
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-11-21
Publisher Place	Romania
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Interleukin-1alpha Generalized Aggressive Periodontitis Sociology DNA Teeth Toll-like receptor 4 Single nucleotide polymorphism Statistics Diseases Immune system
Content Type	Text
Resource Type	Article

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