NDLI: Longitudinal progression of grey matter atrophy morphological characteristics in MCI patients

Content Provider	IEEE Xplore Digital Library
Author	Guihong Yuan Zhizheng Zhuo Haiyun Li
Copyright Year	2013
Description	Author affiliation: Sch. of Biomed. Eng., Capital Med. Univ., Beijing, China (Guihong Yuan; Zhizheng Zhuo; Haiyun Li)
Abstract	Objective To investigate the differences of cerebral grey matter atrophy over time between MCI (Mild Cognitive Impairment) and NC (Normal Control), and further investigate the differences of cerebral grey matter atrophy between SMCI (Stable MCI) and PMCI (Progressive MCI). Methods Based on improved VBM-DARTEL method, NC and MCI longitudinal datasets of 3 years were processed. Firstly, the atrophy patterns and atrophy rates of NC and MCI were obtained. Then, the differences of atrophy within some certain cerebral regions between SMCI and PMCI were explored applying the ROI (Regions of Interest) method. Fractal dimensions were also applied to describe the texture features of the atrophy regions within ROIs and differences of atrophy rates were also calculated. Results With the time varying, the atrophy regions were gradually expanding. In MCI, the atrophy pace was faster and the atrophy rate at the same time point was higher than that in NC. By longitudinal comparison between SMCI and PMCI, it was found that the atrophy in PMCI appeared earlier in the hippocampus, the temporal lobe, the cingulate gyrus and the caudate nucleus and showed an increasing atrophy rate and decreasing fractal dimensions. Conclusions VBM-DARTEL method can be applied to study the cerebral grey matter atrophy effectively. The results showed that the cerebral grey matter changing over time was more obvious in MCI, which can be used to diagnose early AD. Compared to SMCI, there appeared more obvious atrophy in some certain regions of cerebral grey matter in PMCI. So these atrophy differences between SMCI and PMCI can be the evidence to identify PMCI and was of help for clinical diagnosis, clinical intervention and clinical treatment of early AD.
Sponsorship	IEEE Beijing Sect.
Starting Page	66
Ending Page	71
File Size	332754
Page Count	6
File Format	PDF
e-ISBN	9781467358873
DOI	10.1109/ICMIPE.2013.6864505
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-10-19
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Atrophy Magnetic resonance imaging Fractal dimension Mild cognitive impairment VBM-DARTEL Atrophy rate Educational institutions Fractals Hippocampus Dementia
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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