NDLI: The influence of nanosecond pulsed field on a double-shelled ellipsoid cell

Content Provider	IEEE Xplore Digital Library
Author	Linying Liu Zheng Mao Jianhua Zhang Na Liu Qing Huo Liu
Copyright Year	2015
Description	Author affiliation: Dept. of Electr. & Comput. Eng., Duke Univ., Durham, NC, USA (Qing Huo Liu) \|\| Dept. of Electron. Sci., Xiamen Univ., Xiamen, China (Linying Liu; Zheng Mao; Jianhua Zhang; Na Liu)
Abstract	When cells are exposed to very short and high strength electric pulses, they will deform from spherical shape to ellipsoidal shape, and these effects may occur on cellular and organelles. Because of their potential clinical applications, selective effects on organelles are of particular interest. In this work, we use the finite element method to investigate the influence of nanosecond pulsed field on a double-shell ellipsoidal cell. The corresponding transmembrane potential (TMP) and pore density are examined to analyze the response of cells to such a short pulse field. Our active model demonstrates that for the prolate double-shelled cell, the TMP and pore density of the nuclear membrane exceed that on the cell membrane. Our calculation may be useful to guide electroporation experiments.
Starting Page	163
Ending Page	164
File Size	257346
Page Count	2
File Format	PDF
e-ISBN	9781479985432
DOI	10.1109/IMWS-BIO.2015.7303829
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-09-21
Publisher Place	Taiwan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Finite element model Transmembrane voltage Shape Conductivity Electroporation Biomembranes Finite element analysis Cell interior Nanobioscience Permittivity Electric fields
Content Type	Text
Resource Type	Article

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