NDLI: Pulsed terahertz spectrometry of excised breast cancer tissue

Content Provider	IEEE Xplore Digital Library
Author	Bowman, T. El-Shenawee, M.
Copyright Year	2013
Description	Author affiliation: Dept. of Electr. Eng., Comput. Electromagn. Group, Univ. of Arkansas, Fayetteville, AR, USA (Bowman, T.; El-Shenawee, M.)
Abstract	Summary form only given. This research involves the use of a terahertz imaging and spectroscopy system to conduct spectrometry on excised breast tissue. Breast cancer lumpectomy is the process of removing a malignant tumor from breast tissue. During the procedure, a portion of the surrounding tissue, known as the margins, is also removed. The margin tissue undergoes examination by a pathologist in order to determine whether there are any cancerous cells remaining in the healthy tissue. Should any additional cancerous tissue be found in the margin, it is considered a positive margin and an additional surgery is required to remove the remaining cancerous tissue. Previous research has shown that the electrical properties of healthy and cancerous tissue from the breast are distinctly different under terahertz frequency illumination, as reported in (P. C. Ashworth, E. Pickwell-MacPherson, E. Provenzano, S. E. Pinder, A. D. Purushotham, M. Pepper, V. P. Wallace, Optics Express, vol. 17, no. 15, July 2009). These results were obtained up to 2 THz. This research will utilize a pulsed terahertz system at the University of Arkansas in order to examine the electrical properties of excised tissue samples. The system is capable of producing radiation in the 0.06 - 4THz spectral range for the applications of terahertz spectroscopy and imaging. Three types of excised breast tissue will be examined using the terahertz spectrometer: fresh, frozen and formalin fixed paraffin embedded (FFPE). The freshly excised tissue will be obtained from the medical breast surgeon collaborator at the University of Arkansas of Medical Sciences, while the other two types will be obtained from tissue banks (e.g. BioServe Company). The selected tissue types have different percentage of water content, therefore the real and imaginary part of their permittivity are expected to differ significantly. The goal of this work is to examine these three types at various regions of tissue ranging from the middle to the margins of the sample. A comparison of the electrical properties of the three types will be conducted across the available frequency range. The outcomes of this research will enable more accurate modeling of the interaction of terahertz waves with breast tissue and hence will lead to better understanding of the terahertz technology in imaging breast tumor margins.
Sponsorship	IEEE Ant. Propag. Soc.
Starting Page	207
Ending Page	207
File Size	84812
Page Count	1
File Format	PDF
e-ISBN	9781479911295
DOI	10.1109/USNC-URSI.2013.6715513
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-07-07
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Spectroscopy Imaging Surgery Breast tissue Educational institutions Breast cancer
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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