NDLI: Modeling and controller design of perfusion system for heart lung machine

Content Provider	IEEE Xplore Digital Library
Author	Dhinakaran, M. Kumar, P.P. Lincon, S.A.
Copyright Year	2014
Description	Author affiliation: Dept. of Instrum. Eng., Annamalai Univ., Annamalai Nagar, India (Dhinakaran, M.; Kumar, P.P.; Lincon, S.A.)
Abstract	In this work modeling and control strategy is presented for the simultaneous control of oxygen and carbon dioxide blood gas partial pressures to be used during cardiopulmonary bypass surgery with heart-lung machine support. As the exchange of blood gases in the artificial extracorporeal lung is a highly nonlinear process comprising varying time delays, uncertainties, and time-varying parameters, it is currently being controlled manually by specially trained perfusionist staff. The new control strategy includes a feedback linearization routine with augmented time-delay compensation and two external linear gain scheduled controllers, for partial oxygen and carbon dioxide pressures. The controllers were robustly tuned and tested in simulations with a detailed artificial lung (oxygenator) model in cardiopulmonary bypass conditions. Furthermore, the controllers were implemented in an ex vivo experiment using fresh porcine blood as a substitute fluid and a special deoxygenation technique to simulate a patient undergoing cardiopulmonary bypass. Both controllers showed robust stability during the experiments and a good disturbance rejection to extracorporeal blood flow changes. This automatic control strategy is proposed to improve patient's safety by fast control reference tracking and good disturbance rejection under varying conditions.
Starting Page	78
Ending Page	84
File Size	6601735
Page Count	7
File Format	PDF
e-ISBN	9781479979875
DOI	10.1109/ICCTET.2014.6966266
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-07-08
Publisher Place	India
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Gases Analytical models Uncertainty Heart-Lung Machine (HLM) Delay effects Conferences CardioPulmonary Bypass (CPB) Blood Gas Analyzer (BGA) Mathematical model Blood
Content Type	Text
Resource Type	Article

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