NDLI: Non-Invasive Image-Based Approach for Early Detection of Prostate Cancer

Content Provider	IEEE Xplore Digital Library
Author	Firjani, A. Khalifa, F. Elnakib, A. Gimel'farb, G. El-Ghar, M.A. Elmaghraby, A. El-Baz, A.
Copyright Year	2011
Abstract	A novel noninvasive approach for early diagnosis of prostate cancer from Dynamic Contrast enhanced Magnetic Resonance Imaging is proposed. The proposed approach consists of four main steps. The first step is to isolate the prostate from the surrounding anatomical structures based on a Maximum a Posteriori estimate of a new log-likelihood function that accounts for the shape priori, the spatial interaction, and the current appearance of the prostate tissues and its background. In the second step, a non-rigid registration algorithm is employed to account for any local deformation that could occur in the prostate during the scanning process due to patient breathing and local motion. In the third step, the perfusion curves that show propagation of the contrast agent into the tissue are obtained from the segmented prostate of the whole image sequence of the patient. In the final step, we collect two features from these curves and use a kn nearest classifier to distinguish between malignant and benign detected tumors. Moreover, in this paper we introduce a new approach to generate color maps that illustrate the propagation of the contrast agent in the prostate tissues based on the analysis of the 3D spatial interaction of the change of the gray level values of prostate voxel using a Generalized Gauss Markov Random Field image model. Finally, the tumor boundaries are determined using a level set deformable model controlled by the perfusion information and the spatial interactions between the prostate voxels. Experimental results on 21 clinical Dynamic Contrast enhanced Magnetic Resonance Imaging data sets yield promising results.
Starting Page	172
Ending Page	177
File Size	1279579
Page Count	6
File Format	PDF
ISBN	9781457721861
DOI	10.1109/DeSE.2011.55
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-12-06
Publisher Place	United Arab Emirates
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Solid modeling Image segmentation Shape DCE-MRI Shape prior 3D Markov--Gibbs random field Non-rigid registration Three dimensional displays Data models Prostate cancer
Content Type	Text
Resource Type	Article

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