NDLI: Analysis of single nanoparticle detection by using 3-dimensionally confined optofluidic ring resonators

Content Provider	IEEE Xplore Digital Library
Author	Hao Li Yunbo Guo Yuze Sun Reddy, K. Xudong Fan
Copyright Year	2010
Description	Author affiliation: Department of Biomedical Engineering, University of Michigan, 1101 Beal Ave., Ann Arbor, 48109, USA (Hao Li; Yunbo Guo; Yuze Sun; Reddy, K.; Xudong Fan)
Abstract	Viral particles are responsible for the majority of human fatal diseases, including Ebola fever, influenza, HIV, SARS, dengue fever, and so on. Those small infectious agents with radius ranging from 1 nm to 800 nm spread and transmit extremely rapidly, and leave very limited time for treatment if humans are infected [1]. The prevention and early diagnosis of those diseases require fast and trace amount detection of virus in liquid and in air. Among many approaches employed, the optical ring resonator based biosensor is one of the most sensitive devices, capable of detecting a single virion or nanoparticle in a real-time and label-free manner [2–3]. In a ring resonator, light circulates and forms whispering-gallery modes (WGMs). When a virion or nanoparticle binds onto the resonator surface, its interaction with the WGM leads to a spectral shift or mode splitting [2–3]. To date, by measuring the wavelength shift, a single influenza particle (50 nm in radius) in liquid has been detected experimentally with a solid microsphere [2]. Recently, by measuring the mode splitting, the detection and sizing of a single nanoparticle (30 nm in radius) in air have also been demonstrated with a microtoroid [3]. However, despite their excellent sensing performance, both structures lack of an efficient fluidic system to rapidly deliver samples to the sensing head (i.e., the ring resonator), which may significantly lengthen the detection time, in particular, when detecting a single nanoparticle.
Starting Page	324
Ending Page	325
File Size	596233
Page Count	2
File Format	PDF
ISBN	9781424471119
e-ISBN	9781424471133
DOI	10.1109/ACP.2010.5682536
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-12-08
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Sensitivity Biosensors Optical sensors Optical ring resonators Electric fields Optical surface waves
Content Type	Text
Resource Type	Article

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