NDLI: Invited: A protein domain-centric approach to translational bioinformatics

Content Provider	IEEE Xplore Digital Library
Author	Kann, M.G.
Copyright Year	2012
Description	Author affiliation: Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, USA (Kann, M.G.)
Abstract	Identifying the functional context for key molecular disruptions in complex diseases is a major goal of modern medicine that will lead to improved preventive clinical approaches, earlier diagnosis and more effective personalized disease therapies. Most available resources for visualization and analysis of disease mutations centered on gene analysis and do not leverage information about similarity on the functional context of the mutation. In addition, gene-centric approaches are confounded because genes may share some functional subunits, or protein domains, but not others. We have built a resource for domain mapping of disease mutations, DMDM, a protein domain database in which each disease mutation can be displayed by its protein domain location. DMDM provides a unique domain-level view where human coding mutations are mapped to protein domains by highlighting molecular relationships among mutations from different diseases that might not have been discovered with traditional gene-centric visualization tools. We have also developed a statistical method, the domain significance scores (DSScores), to assess the significance of disease mutation clusters on protein domains. When we applied the DS-Scores to human data and identified domain hotspots in oncogenes, tumor suppressors, and genes associated with Mendelian diseases.
Starting Page	1
Ending Page	1
File Size	58321
Page Count	1
File Format	PDF
ISBN	9781467313209
e-ISBN	9781467313216
e-ISBN	9781467313193
DOI	10.1109/ICCABS.2012.6182622
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-02-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Context Translational bioinformatics Humans Data visualization Prediction of domain-domain interactions Protein domain Coevolution Bioinformatics Marine vehicles Diseases
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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