NDLI: Stepwise modelling of biochemical pathways based on qualitative model learning

Content Provider	IEEE Xplore Digital Library
Author	Zujian Wu Wei Pang Coghill, G.M.
Copyright Year	2013
Description	Author affiliation: Sch. of Natural & Comput. Sci., Univ. of Aberdeen, Aberdeen, UK (Zujian Wu; Wei Pang; Coghill, G.M.)
Abstract	Modelling of biochemical pathways in a computational way has received considerable attention over the last decade from biochemistry, computing sciences, and mathematics. In this paper we present an approach to evolutionarily stepwise constructing models of biochemical pathways by a qualitative model learning methodology. Given a set of reactants involved in a target biochemical pathway, atomic components can be generated and preserved in a components library for further model composition. These synthetic components are then reused to compose models which are qualitatively evaluated by referring to experimental qualitative states of the given reactants. Simulation results show that our stepwise evolutionary qualitative model learning approach can learn the relationships among reactants in biochemical pathway, by exploring topology space of alternative models. In addition, synthetic biochemical complex can be obtained as hidden reactants in composed models. The inferred hidden reactants and topologies of the synthetic models can be further investigated by biologists in experimental environment for understanding biological principles.
Starting Page	31
Ending Page	37
File Size	1159394
Page Count	7
File Format	PDF
e-ISBN	9781479915682
DOI	10.1109/UKCI.2013.6651284
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-09-09
Publisher Place	UK
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Analytical models Biological system modeling Computational modeling Differential equations Biochemistry Libraries Mathematical model
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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