NDLI: Microfluidic platforms for size-based cell sorting

Content Provider	IEEE Xplore Digital Library
Author	Karunanidhi, S. Lum, M.W. Nagurla, S.R. Tang, W.C.
Copyright Year	2013
Description	Author affiliation: Dept. of Biomed. Eng., Univ. of California, Irvine, Irvine, CA, USA (Karunanidhi, S.; Lum, M.W.; Nagurla, S.R.; Tang, W.C.)
Abstract	We report on the design, fabrication, and test results of a set of microfluidic devices with channels designed to promote fluidic hydrodynamic forces to sort and separate cells based on cell sizes. A set of 14 devices were made from polydimethylsiloxane (PDMS) molded from photolithographically patterned SU-8. The spiral fluidic channels with specific numbers of turns, widths, and outer diameters were designed with branches at strategic locations along the length to divert separated particles into collection chambers. A mixture of polystyrene particles of two different diameters (7 and 20 μm) was used as the test solution to determine the sorting efficiencies. Theoretical analyses of the designed performance were based on previously published equations and were found to be within practical agreement. The optimized performance was consistently close to 90% capture and isolation efficiencies from a mixture of up to 1:100,000 of 20-μm-to-7-μm particles at a flow rate of 4.0 $mL·min^{-1}.$
Starting Page	27
Ending Page	31
File Size	1371346
Page Count	5
File Format	PDF
e-ISBN	9781479926909
DOI	10.1109/NANOMED.2013.6766310
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-11-10
Publisher Place	Thailand
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Platforms Spirals Prototypes Microfluidic Microfluidics Blood Cells Cancer Tumors Sorting
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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