NDLI: Immune system control

Content Provider	IEEE Xplore Digital Library
Author	Mohler, R.R. Barton, C.F.
Copyright Year	1975
Description	Author affiliation: Oregon State University, Corvallis, Oregon (Mohler, R.R.) \|\| Oregon State University, Corvallis Oregon (Barton, C.F.)
Abstract	A brief functional description of the manner in which the immune system seems to control disease and infection is presented. Recent hypotheses in immunology and the role of a model to support this work are discussed. This leads to the derivation of a simple model for the generation of antibodies from clonal selection theory. A survey of related research is provided along with model assumptions and shortcomings. Model innovations are suggested to explain the more intense secondary response to a repeated invasion by a particular alien as well as the immunoglobulin switch-over phenomenon. A case is established for more complex models which include two major classes of lymphocytes (white blood cells) termed T cells and B cells, their functional subclasses, their interaction, immune tolerance and cell mediated immunity. While plausible arguments are presented for further model development, it is noted that immunology, as supported by on-going experimental research, is such a rapidly changing science that a final model is hardly imminent. Plans are outlined for continued model development in sequence with new experimental evidence. It is seen that stochastic control and adaptive structures play a significant role in the immune processes.
Starting Page	396
Ending Page	401
File Size	508772
Page Count	6
File Format	PDF
DOI	10.1109/CDC.1975.270717
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1975-12-10
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Immune system Control systems Biomembranes Permeability Neuromuscular Viruses (medical) Protection Cancer
Content Type	Text
Resource Type	Article

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