NDLI: Mining complex patterns from protein surfaces

Content Provider	IEEE Xplore Digital Library
Author	Baldacci, L. Golfarelli, M.
Copyright Year	2005
Description	Author affiliation: DEIS, Bologna Univ., Italy (Baldacci, L.; Golfarelli, M.)
Abstract	In the domain of bioinformatics, the role played in the biological process by proteins, that act as transmitters and receivers of information thus ruling the mechanisms that determine how organic systems function, has great importance. Recent studies produced evidence of a strict correlation between the surface characteristics of proteins and the way they interact. In this paper we propose an original approach for discovering protein similarities based on their surface characteristics represented in terms of surface patterns. The approach starts from a detailed representation of the protein surfaces and determines a set of characteristic regions that defines a compact representation of the protein surface that is the input for an ad-hoc data mining technique used to find the frequent patterns. Tests, carried out on a benchmark dataset of molecules with suitably designed surface mutations, show that surface patterns can be used to correctly classify groups of similar proteins.
Starting Page	590
Ending Page	594
File Size	317245
Page Count	5
File Format	PDF
ISBN	0769524249
ISSN	15294188
DOI	10.1109/DEXA.2005.133
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-08-22
Publisher Place	Denmark
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Data mining Bioinformatics Biological processes Transmitters Medical tests Benchmark testing Genetic mutations Chemistry Chemicals
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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