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Content Provider | IEEE Xplore Digital Library |
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Author | Yongfeng Yuan Kuanquan Wang Kharsche, S. Henggui Zhang |
Copyright Year | 2011 |
Description | Author affiliation: The University of Manchester, Manchester, UK (Kharsche, S.; Henggui Zhang) || Harbin Institute of Technology, Harbin, China (Yongfeng Yuan; Kuanquan Wang) |
Abstract | Myocardial ischemia (MI) is the leading cause of morbidity and mortality in the industrialized world. The Gautier et al reported that late sodium current (INaL) kinetics was remodelled by Lysophosphatidylcholine (LPC) and provided some new insights into the underlying mechanisms of MI. In this simulation study, the kinetics of LPC-induced sodium channels was incorporated into human ventricular cell models and into 1D and 2D transmural tissue model. The simulations found that the increased heterogeneity of repolarisation by LPC significantly prolonged QT interval and might be anticipated to be proarrhythmic. Meanwhile, LPC would be anticipated to decrease refractoriness of cells, increase temporal width of vulnerable window (VW) and reduce the wavelength necessary for re-entrant circuits causing an increase susceptibility to arrhythmogenesis. Hence, the INaL regulated by LPC can be a potential therapeutic target in patients with ischemic heart disease. |
Starting Page | 653 |
Ending Page | 656 |
File Size | 222446 |
Page Count | 4 |
File Format | |
ISBN | 9781457706127 |
ISSN | 02766547 |
e-ISBN | 9781457706110 |
Language | English |
Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
Publisher Date | 2011-09-18 |
Publisher Place | China |
Access Restriction | Subscribed |
Rights Holder | Creative Commons Attribution License 2.5 (CCAL) |
Subject Keyword | Computational modeling Humans Heart Mathematical model Kinetic theory Myocardium Data models |
Content Type | Text |
Resource Type | Article |
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