NDLI: Transdermal scopolamine increases heart rate variability by selective parasympathetic stimulation

Content Provider	IEEE Xplore Digital Library
Author	Vybiral, T. Bryg, R.J. Maddens, M.A. Lehmann, M.H. Boden, W.E.
Copyright Year	1989
Description	Author affiliation: Div. of Cardiology, Wayne State Univ., MI, USA (Vybiral, T.; Bryg, R.J.; Maddens, M.A.; Lehmann, M.H.; Boden, W.E.)
Abstract	Summary form only given. It was hypothesized that the transdermal application of low-dose scopolamine using the unique therapeutic system Transderm Scop would selectively augment parasympathetic cardiac reflex activity and increase heart rate variability. The authors tested several indices of heart rate variability in 31 healthy adults (age: 31+or-7 years) after 234 hours of exposure to one patch of transdermal scopolamine. It was confirmed that transdermal scopolamine markedly increases heart rate variability in healthy human adults. Power spectrum analysis of R-R intervals appears to be a very sensitive measure of changes occurring within the autonomic nervous system. Changes in the power of the 0.25-Hz band, in particular, reliably indicate changes in parasympathetic nervous system activity. Transdermal scopolamine thus holds promise as a therapeutic intervention for selectively enhancing abnormally decreased vagal tone in patients after myocardial infarction, whose reduced heart rate variability may be restored to normal.<>
File Size	84672
File Format	PDF
ISBN	0818621141
DOI	10.1109/CIC.1989.130477
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1989-09-19
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Heart rate variability Parasympathetic nervous system Myocardium Electrocardiography Testing Power system reliability Cardiology Hospitals Pharmaceuticals Dermis
Content Type	Text
Resource Type	Article

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