NDLI: Low Noise Microelectrode Array Signal Headstage Pre-amplifier for In-Vitro Neuron Culture

Content Provider	IEEE Xplore Digital Library
Author	Fambrini, F. Barreto, M.A. Hiroki Saito, J.
Copyright Year	2014
Description	Author affiliation: Grad. Course in Comput. Sci., Fac. of Campo Limpo Paulista (FACCAMP), Campo Limpo Paulista, Brazil (Fambrini, F.; Barreto, M.A.) \|\| Fed. Univ. of Sao Carlos - UFSCar, Sao Carlos, Brazil (Hiroki Saito, J.)
Abstract	MEA (Micro-Electrode Array) is a very useful device for extra cellular signal recording of in-vitro cultured neurons or network of neurons. It can be used for the research of the neuronal network dynamics, recording with the microelectrodes the spontaneous activity signals of the network of neurons, and the evocated physiological signals in response to chemical or electrical stimulations. The electrophysiological signals measured by the microelectrodes are in micro volt order of magnitude, so that these signals should be amplified a factor of 1000 (or 30 dB) by a two-phase amplification system, with special techniques that avoid the amplification of noise. This paper describes the design of a low noise first stage of the MEA signal amplifier, denoted head stage amplifier. The design, simulation and construction of a prototype of the head stage amplifier, and a pass-band filter, are described. The results show the feasibility of the proposal, leading to the construction of a prototype amplification system for the whole MEA with 60 microelectrodes.
Starting Page	447
Ending Page	450
File Size	581115
Page Count	4
File Format	PDF
ISBN	9781479944354
ISSN	23729198
DOI	10.1109/CBMS.2014.39
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-05-27
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	neuron Multi-electrode-array headstage amplifier filters electrophysiological signal MEA
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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