NDLI: Toward a systems biology software toolkit

Content Provider	IEEE Xplore Digital Library
Author	Johann, D.J. McGuigan, M.D. Tomov, S. Blum, E. Whiteley, G.R. Petricoin ,. E.F. Liotta, L.A.
Copyright Year	2004
Description	Author affiliation: Nat. Inst. of Health, Bethesda, MD, USA (Johann, D.J.)
Abstract	Insight to complex problems may be revealed when domain data sets are viewed or structured in new and innovative ways. Systems approaches to biomedical problems fundamentally involve forecasting, and a deliberate integration of diverse data sources. Adding a clinical proteomic dimension to these developing efforts affirms the ultimate aims of enhanced diagnostic prediction, maximizing the possibility for a rational therapy individualized to a patient's pathologic process, and thus, improving patient outcomes. Consistent with these evolving goals, computer-aided diagnostic systems are rapidly approaching a new paradigm involving the integration of medical imaging with high throughput molecular medicine tests. As medical imaging systems become more sensitive in finding anatomic anomalies, their lack of specificity becomes much more of a clinical dilemma. Proteomic tests may be used to help resolve the lack of specificity of imaging findings. A synergistic test composed of a targeted imaging study correlated with a genomic or proteomic test(s), offers the potential of a tremendous medical advancement. Bioinformatic software toolkits are crucial components of these systems. Open source software provides a mechanism for leveraging existing toolkits, sharing expertise, accelerating development, and furthering biomedical, software, and systems sciences in new and complex multi-disciplinary fields. Our evolving toolkit utilizes components from several existing open source projects. It will initially be customized for serum proteomic pattern diagnostics, which will be used in the upcoming NCI/CCR Clinical Trial involving the monitoring for ovarian cancer recurrence.
Sponsorship	IEEE Comput. Soc. Tech. Committee on Computational Medicine Texas Tech Univ. College of Eng
Starting Page	500
Ending Page	505
File Size	507434
Page Count	6
File Format	PDF
ISBN	0769521045
ISSN	10637125
DOI	10.1109/CBMS.2004.1311764
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-06-25
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Systems biology Software systems Software tools Biomedical imaging Proteomics Medical tests Open source software Medical diagnostic imaging Bioinformatics Medical treatment
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Computer Science Applications

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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