NDLI: Model-Checking Based Approaches to Parameter Estimation of Gene Regulatory Networks

Content Provider	IEEE Xplore Digital Library
Author	Mizera, A. Jun Pang Qixia Yuan
Copyright Year	2014
Description	Author affiliation: Fac. of Sci., Technol. & Commun., Univ. of Luxembourg, Luxembourg, Luxembourg (Mizera, A.; Jun Pang; Qixia Yuan)
Abstract	The expression of genes is a fundamental process in living cells, both eukaryotic and prokaryotic. The regulation of gene expression is achieved via sophisticated networks of interactions between DNA, RNA, proteins, and small chemical compounds. The qualitative and quantitative characterisation of interactions between genes is one of the major current research targets in systems biology. In this PhD research project, we view gene regulatory networks as Markov chains, resulting from popular formalisation frameworks such as Dynamic Bayesian Networks and Probabilistic Boolean Networks. This will allow us to reason about both the structure and strength of gene interactions. Our goal is to develop new algorithms and tools, which are tailored for the modelling and analysis of gene regulatory networks, by exploring model checking techniques that have been developed and widely used in computer science. More specifically, we will combine model checking techniques with sampling and optimisation methods from the literature to derive new techniques to solve the parameter estimation problem of Markov models of gene regulatory networks.
Starting Page	206
Ending Page	209
File Size	116553
Page Count	4
File Format	PDF
e-ISBN	9781479954827
DOI	10.1109/ICECCS.2014.38
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-08-04
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Biological system modeling Markov processes Computational modeling Steady-state Systems biology Analytical models Model checking biological systems steady states Markov chains parameter estimation
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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