NDLI: Inducing and suppressing ventricular fibrillation: A simulation study with three-dimensional heart model and experimental data

Content Provider	IEEE Xplore Digital Library
Author	Wei, Darning Okazaki, Osamu Harumi, Kenichi Harasawa, Eishi Musha, Toshimitsu
Copyright Year	1992
Description	Author affiliation: Nakano National Chest Hospital, Japan (Okazaki, Osamu; Harumi, Kenichi) \|\| Dept. of Electric Engineering, Science University of Tokyo, Japan (Musha, Toshimitsu) \|\| Electrocardiography Division, Nihon Koden Corporation 1-31-4 Nishiochiai, Shinjuku-ku, Tokyo 161, Japan (Wei, Darning; Harasawa, Eishi)
Abstract	Ventricular fibrillation was simulated using three-dimensional heart model incorporating anatomic and electrophysiologic details. A parameter relating restitution of premature action potential durations to coupling interval of stimulation was defined and incorporated into the heart model to simulate the cell dynamics. Conduction delay during relative refractory period was also taken into account. During sinus pacing extra-stimuli were applied to the left ventricular epicardium of the heart model. As long as up to 8 seconds of the sequential excitation process of the heart model and the resultant electrocardiograms on a torso model were computed. Ventricular fibrillation was successfully induced and suppressed by employing experimental data obtained from dogs before and during the infusion of antiarrhythmic drugs.
Starting Page	400
Ending Page	402
File Size	392203
Page Count	3
File Format	PDF
ISBN	0780307852
DOI	10.1109/IEMBS.1992.5761031
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1992-10-29
Publisher Place	France
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Heart Computational modeling Data models Computers Couplings Lead Electric potential
Content Type	Text
Resource Type	Article

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