NDLI: Electrochemistry in microscopic domains: a model system to interpret voltammetry measurements in restricted biological spaces

Content Provider	IEEE Xplore Digital Library
Author	Kashyap, R. Gratzl, M.
Copyright Year	1997
Description	Author affiliation: Dept. of Biomed. Eng., Case Western Reserve Univ., Cleveland, OH, USA (Kashyap, R.)
Abstract	The motivation of this work is to provide a simple and robust model system to help quantitatively interpret electrochemical measurements made in restricted biological domains, such as in or near single biological cells, or in microscopic tissue cavities an example being dopamine release measurements in brain. Microscopic aqueous sample droplets of nano- to picoliter volumes were formed on the bottom of a polystyrene dish under heptane which was presaturated with distilled water to keep the droplets stable. The electrochemical cell consisted of a bevelled carbon fiber microdisk working electrode and a reference electrode with a miniature junction. This latter was made of a diffusional microburet (DMB), previously used for diffusional reagent delivery into similar size droplets, containing 0.1 M KCl and an inserted chloridized silver wire. Both electrodes had a nominal tip diameter of 7.5 /spl mu/m. Cyclic voltammetry and chronoamperometry in droplets of 3.3 mM ruthenium hexaammine trichloride in 0.1 M KCl solution were performed with this system. The experiments revealed for the first time major deviations in microelectrode behavior in microscopic domains as compared to bulk volume. These results must be taken into account to conduct and interpret voltammetry measurements in restricted biological spaces correctly. The methodology developed has, however, more general analytical and physicochemical applications as well.
Starting Page	2357
Ending Page	2360
File Size	438229
Page Count	4
File Format	PDF
ISBN	0780342623
ISSN	1094687X
DOI	10.1109/IEMBS.1997.756790
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1997-10-30
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Microscopy Electrodes Biological system modeling Kirchhoff's Law Robustness Brain modeling Biological cells Biological tissues Nanobioscience Digital multimedia broadcasting
Content Type	Text
Resource Type	Article

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