NDLI: The paired-pulse index: a measure of vigilance state-dependent changes during maturation

Content Provider	IEEE Xplore Digital Library
Author	Bronzino, J.D. Blaise, J.H.
Copyright Year	1996
Description	Author affiliation: Dept. of Eng. & Comput. Sci., Trinity Coll., Hartford, CT, USA (Bronzino, J.D.)
Abstract	The response of the hippocampal dentate granule cell population to paired-pulse stimulation of the perforant path obtained during quiet waking (QW), slow-wave sleep (SWS) and REM sleep was examined in freely-moving rats at 15, 30, and 90 days of age. The response to paired-pulse stimulations applied over a range of interpulse intervals (IPIs) was used to construct a paired-pulse index (PPI) Indicative of the modulatory control exerted on dentate granule cell excitability. In comparison to 90 day old animals, PPIs obtained from 15-day old rats during QW indicated a markedly lower levels of early inhibition and facilitation and a relative lack of late inhibitory modulation. Values of the PPI obtained from 30 day old rats fell intermediate between the 15 day and adult groups. Adult rats showed an absence of facilitation and a decrease in late inhibition during REM sleep. Although no significant vigilance state-dependent changes in the PPI were obtained for 15or 30- day old animals, these results indicate the PPI is an effective measure of the normal maturation of the modulation of dentate granule cell activity.
Starting Page	1562
Ending Page	1563
File Size	219462
Page Count	2
File Format	PDF
ISBN	0780338111
DOI	10.1109/IEMBS.1996.647552
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1996-10-31
Publisher Place	Netherlands
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Rats Sleep Engineering in Medicine and Biology Society Animals Pulse modulation Embryo Engineering in medicine and biology Computer science Educational institutions Laboratories
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in