NDLI: Modulation of propagation from an ectopic focus by electrical load and by extracellular potassium concentration

Content Provider	IEEE Xplore Digital Library
Author	Wagner, M.B. Golod, D. Wilders, R. Verheijck, E.E. Joyner, R.W. Kumar, R. Jongsma, H.J. van Ginneken, A.C.G. Goolsby, W.N.
Copyright Year	1996
Description	Author affiliation: Bioeng. Graduate Group, California Univ., Berkeley, CA, USA (Wagner, M.B.)
Abstract	Cardiac arrhythmias may be due to spontaneous automatic activity from an ectopic focus. We have developed a technique in which a computer model of an ectopic focus (represented by an SA Node cell model), running in real time, can be coupled by a variable conductance, G/sub c/, to a real ventricular cell. We used this technique to investigate the effects of G/sub c/, cell size, and elevated potassium on the ability of an ectopic focus to successfully drive the ventricular cell. For the hybrid cell pair there are three possible outcomes in the steady state: (1) pacing of the SAN model cell but not driving of the ventricular cell, (2) cessation of pacing, or (3) successful pacing of the SAN model cell and driving of the ventricular cell. Elevation of potassium concentration increases both the lower and upper bound of the values of G/sub c/ which define the successful pacing and driving range.
Starting Page	1246
Ending Page	1247
File Size	264550
Page Count	2
File Format	PDF
ISBN	0780338111
DOI	10.1109/IEMBS.1996.652794
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1996-10-31
Publisher Place	Netherlands
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Extracellular Coupling circuits Storage area networks Rabbits Pediatrics Physiology Ischemic pain Biomembranes Mathematical model Biological system modeling
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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