NDLI: The effect of interelectrode distances on measurements of the local potential gradient of the propagating cardiac excitation at a microscopic size scale

Content Provider	IEEE Xplore Digital Library
Author	Hofer, E. Schafferhofer, I. Mohr, G.
Copyright Year	1995
Description	Author affiliation: Inst. fur Med. Phys. und Biophys., Graz Univ., Austria (Hofer, E.)
Abstract	Cardiac excitation spread at a microscopic (<200 /spl mu/m) size scale can be seen as a propagating signal in a discrete electrical network with stochastically distributed electrical discontinuities at the sites of cell to cell connections. In order to test the hypothesis if this discontinuous spatio-temporal process can also be detected as discontinuous distribution of extracellular potentials the authors developed high-resolution sensor arrays in thin-film technique (180 /spl mu/m to 20 /spl mu/m interelectrode spacing) as well as array amplifiers and data acquisition systems. The time course of signals from bipolar recordings (gradients) and from quadrupolar recordings (field magnitude) was compared for different interelectrode distances. All signals were be taken from a set of 25 signals obtained simultaneously by one array recording. The measurements showed that from 280 /spl mu/m down to the smallest possible interelectrode distance of 20 /spl mu/m the measured the gradient of the local potential increased by a factor of two. This local field parameter varied substantially within an area of 200/spl times/200 /spl mu/m/sup 2/.
Starting Page	61
Ending Page	62
File Size	292264
Page Count	2
File Format	PDF
ISBN	0780324757
DOI	10.1109/IEMBS.1995.575000
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1995-09-20
Publisher Place	Canada
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Sensor arrays Electrodes Microscopy Extracellular Sensor systems Thin film sensors Data acquisition System testing Biomembranes Computer simulation
Content Type	Text
Resource Type	Article

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