NDLI: Dielectric study of the programmed cell death, apoptosis, in human leukemia

Content Provider	IEEE Xplore Digital Library
Author	Kanapitsas, A. Vartzeli-Nikaki, P. Konsta, A.A. Visvardis, E.-E. Sideris, E.G.
Copyright Year	2005
Description	Author affiliation: Dept. of Phys., Nat. Tech. Univ. of Athens, Greece (Kanapitsas, A.; Vartzeli-Nikaki, P.; Konsta, A.A.)
Abstract	Previous work in our laboratories showed that Broadband Dielectric Spectroscopy (DRS) reveals the very early physical events on damaged DNA which lead to the disruption of the DNA weak stacking forces. We followed up the evolution of this early physical damage into chemical damage within human cells. The induced chemical lesions result in biological effects including the initiation of programmed cell death, apoptosis, a mechanism resulting in extensive disruption of the external cell membranes. Using sensitive bio-methodologies we revealed that the early DNA damage was finally initiating apoptosis only when the damage was overwhelming intrinsic repair mechanisms. Finally, we were able to study the early stages of membrane alteration, associated with apoptosis, by measuring modifications in the dielectric properties of the cell membrane. It was found that in cells from donors with the chronic lymphocytic leukemia (CLL-cells), which exhibit a higher frequency of apoptosis, the values of the real and the imaginary part of the dielectric permittivity, e*, i.e. e' and e" respectively, and of the alternate field specific conductivity, s/sub ac/ as a function of frequency, were higher than those of the healthy donors, in which apoptosis occurs at very low frequency.
Starting Page	497
Ending Page	500
File Size	1877491
Page Count	4
File Format	PDF
ISBN	0780391160
DOI	10.1109/ISE.2005.1612434
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-09-11
Publisher Place	Brazil
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Dielectrics Humans DNA Cells (biology) Biomembranes Frequency Chemicals Laboratories Electrochemical impedance spectroscopy Stacking
Content Type	Text
Resource Type	Article

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