NDLI: Imaging gene expression and signal transduction pathway activity

Content Provider	IEEE Xplore Digital Library
Author	Gelovani, J. Blasberg, R.
Copyright Year	2002
Description	Author affiliation: Memorial Sloan-Kettering Cancer Center, New York, NY, USA (Gelovani, J.; Blasberg, R.)
Abstract	Molecular imaging is a new field of study that develops the technology to image disease on a cellular or genetic level rather than on a gross anatomical level. The ability to non-invasively monitor different cellular molecular-genetic processes in vivo is the goal of molecular imaging. The pace of progress in this field is encouraging, particularly in the imaging of gene expression. Recent advances in molecular biology have revealed the genetic sequences and genetic mutations that cause diseases including cancer, functional activities of many genes and proteins, as well as the functional properties of various cellular receptors and their ligands. These discoveries improved our understanding of the fundamental mechanisms of various diseases that lead to the burst of novel genetically based therapies. These discoveries are now being extended into radiologic sciences aiming at non-invasive visualization of the molecular-genetic processes involved in various diseases, non-invasive monitoring of responses to therapy on a molecular level, and to assess the effectiveness of gene transfer and expression in novel gene therapy protocols.
Sponsorship	IEEE Signal Processing Soc
Starting Page	820
Ending Page	823
File Size	299496
Page Count	4
File Format	PDF
ISBN	078037584X
DOI	10.1109/ISBI.2002.1029385
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-07-07
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Gene expression Diseases Molecular imaging Monitoring Medical treatment In vivo Cells (biology) Sequences Genetic mutations Cancer
Content Type	Text
Resource Type	Article

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