NDLI: A physical model of potential energy profiles of ions going through a biological membrane channel

Content Provider	IEEE Xplore Digital Library
Author	Zou, C.H. Cheng, K.
Copyright Year	1995
Description	Author affiliation: Univ. of Miami Sch. of Med., FL, USA (Zou, C.H.; Cheng, K.)
Abstract	To attempt to explain what determines a single particle (an ion or an ion group) penetration of a cell membrane channel, a physical model of potential energy profiles V/sub 2/(x) of a channel is proposed, based on the authors' previous study of one dimensional (1-D) steady state Schrodinger equation in a single particle system and in a time independent field. In this model, a V/sub 2/(x) is simplified as an effective constant height of potential energy barrier V/sub 2/ in a channel to obtain analytical solutions in mathematics. This model elucidates that: (1) Ion selectivity of a channel is determined by V/sub 2/. V/sub 2/ is divided into a V/sub 2c/ for a cation and V/sub 2a/ for an anion. V/sub 2c/ and V/sub 2a/ may be or may be not the same value depending on electrical characteristics of the particles and the channel. It is called a cation channel if a V/sub 2c/ is much lower than a V/sub 2a/ and vice versa. It is called a cation-anion cotransporter if a V/sub 2e/ and a V/sub 2a/ are equal or almost equal. (2) Whether a particle can penetrate through a channel is mostly determined by the repulsion energies (barriers) rather than the attraction energies (wells). (3) A channel's conformation can be changed when the channel is stimulated strongly enough. The variation of the conformation could influence V/sub 2/(x) and V/sub 2/, and eventually result in open or close of the channel.
Starting Page	27
Ending Page	29
File Size	237247
Page Count	3
File Format	PDF
ISBN	0780320832
DOI	10.1109/SBEC.1995.514421
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1995-04-07
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Biological system modeling Potential energy Biomembranes Mathematics Thermal force Steady-state Schrodinger equation Mathematical model Electric variables Kinetic energy
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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