NDLI: An in vitro time study of distensibility in porcine aortas using high resolution X-ray CT

Content Provider	IEEE Xplore Digital Library
Author	Medynsky, A.O. Sherebrin, M.H. Rankin, R.N. Holdsworth, D.W. Roach, M.R.
Copyright Year	1996
Description	Author affiliation: Adv. Imaging Labs., Robarts Res. Inst., London, Ont., Canada (Medynsky, A.O.)
Abstract	Porcine aortas have been used extensively for medical research because of their availability and similarities to human aortas. The elastic properties of porcine aortas have also been studied and quantified, yet there has been no initiative to study the effect of time on the elastic properties of in vitro porcine aortic specimens when pressurized with humidified air, which the authors use as contrast for the arterial wall when X-ray imaging (CT) is used to determine the effect of pressure on aortic dimensions. These experiments were designed to clarify whether the use of humidified air to pressurize the specimens affects the elastic properties of the tissue over a period of time. Seven porcine aortas (four thoracic and three abdominal) studied. The specimens were cleaned of adipose tissue and made pressure tight by tying off the side branches. Each specimen was pressurized from 4 to 24 kPa with humidified air and imaged on days 0, 3, 5 and 7 by mounting the aortas in a high-resolution laboratory computed tomography (CT) scanner. Between imaging sessions the aortas were stored in a saline solution and refrigerated at 5/spl deg/C. Distensibility was then calculated from luminal perimeter measurements obtained from 2-dimensional cross-sectional slices through the aorta at six different pressures. Approximately 50 minutes were needed to acquire each set of data. The lumen perimeter increased after each imaging session, presumably due to creep. The distensibility of the thoracic aortas decreased in the range of 4.2-12.7% over the duration of the experiments and their perimeter-pressure curves were linear. The distensibilities of the abdominal aortas varied considerably from an increase of 16.5% to a decrease of 58%, and their perimeter-pressure curves were nonlinear. The wide range in results, particularly with the abdominal aortas, indicates that further studies are required.
Starting Page	281
Ending Page	284
File Size	341763
Page Count	4
File Format	PDF
ISBN	0780331311
DOI	10.1109/SBEC.1996.493169
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1996-03-29
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	In vitro Biomedical imaging Computed tomography Abdomen Humans Arteries X-ray imaging Laboratories High-resolution imaging Refrigeration
Content Type	Text
Resource Type	Article

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