NDLI: A bioinformatics approach for investigating the determinants of Drosha processing

Content Provider	IEEE Xplore Digital Library
Author	Karathanasis, N. Tsamardinos, I. Poirazi, P.
Copyright Year	2013
Description	Author affiliation: Inst. of Mol. Biol. & Biotechnol., FORTH, Heraklion, Greece (Karathanasis, N.; Tsamardinos, I.) \|\| Dept. of Comput. Sci., Univ. of Crete, Heraklion, Greece (Poirazi, P.)
Abstract	We use a bioinformatics approach to search for the biological features that determine the cleavage site of the Microprocessor complex (or Drosha) within known miRNA hairpins. Towards this goal, we employ a previously developed methodology, termed DuplexSVM, which can accurately identify the four ends of a miRNA:miRNA* duplex. Here we use DuplexSVM to study how the Drosha determines its cleavage site. We perform in silico mutagenesis experiments on 142 hairpins by changing the distance of the Drosha site from the loop tip or the stem - single stranded tails junction by adding or removing matching nucleotides. Our results suggest that the Drosha cleavage site is mainly determined by its distance from the terminal loop tip.
Sponsorship	IEEE Comput. Soc.
Starting Page	1
Ending Page	4
File Size	178932
Page Count	4
File Format	PDF
ISBN	9781479931637
DOI	10.1109/BIBE.2013.6701569
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-11-10
Publisher Place	Greece
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Junctions Microprocessors RNA Biological system modeling Bioinformatics Animals
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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