NDLI: Non-Monotonic Radio-Sensitivity over Tumor Volumes on Adjuvant Radio Therapy A New Insight on Cell Killing and Modeling

Content Provider	IEEE Xplore Digital Library
Author	Yang, J.Y. Niemierko, A. Yang, M.Q. Youping Deng
Copyright Year	2007
Description	Author affiliation: Harvard Med. Sch., Boston (Yang, J.Y.)
Abstract	Adjuvant Radiotherapy (RT) after surgical removal of tumors proved beneficial in long-term tumor control and treatment planning. For many years, it has been well concluded that radio-sensitivities of tumors upon radiotherapy decrease according to the sizes of tumors and RT models based on Poisson statistics have been used extensively to validate clinical data. We found that Poisson statistics on RT is actually derived from bacterial cells despite of many validations from clinical data. However cancerous cells do have abnormal cellular communications and use chemical messengers to signal both surrounding normal and cancerous cells to develop new blood vessels and to invade, to metastasis and to overcome intercellular spatial confinements in general. We therefore investigated the cell killing effects on adjuvant RT and found that radio-sensitivity is actually not a monotonic function of volume as it was believed before. We present detailed analysis and explanation to justify above statement. Based on Niemierko's EUD, we present an equivalent radio-sensitivity model. We conclude that radio sensitivity is a sophisticated function over tumor volumes, since tumor responses upon radio therapy also depend on cellular communications.
Starting Page	524
Ending Page	531
File Size	2185936
Page Count	8
File Format	PDF
ISBN	9781424415090
DOI	10.1109/BIBE.2007.4375611
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-10-14
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Neoplasms Medical treatment Statistics Cells (biology) Surgery Radio control Microorganisms Chemicals Blood vessels Metastasis Equivalent Radio-sensitivity Model Radiotherapy Microscopic Tumor Tissue Poisson Statistics Radio-sensitivity and Cell Killing Niemierko's EUD
Content Type	Text
Resource Type	Article

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