NDLI: Regulating gene expression using optimal control theory

Content Provider	IEEE Xplore Digital Library
Author	Yunlong Liu Hui Bin Sun Yokota, H.
Copyright Year	2003
Description	Author affiliation: Biomed. Eng. Program, Indiana Univ., Indianapolis, IN, USA (Yunlong Liu; Hui Bin Sun; Yokota, H.)
Abstract	We described development of a novel genome-based model-driven strategy useful for regulating eukaryotic gene expression. In order to extract biologically meaningful information from a large volume of mRNA expression data, we built previously a PROmoter-Based Estimation (PROBE) model. The PROBE model allowed us to establish a quantitative relationship between transcription-factor binding motifs in regulatory DNA sequences and mRNA expression levels. Here, we extended PROBE formulation to derive an optimal control law for gene regulation. The responses to shear stress in human synovial cells were chosen as a model biological system, and the system dynamics was identified from the expression pattern of the genes involved in degradation and maintenance of extracellular matrix. In order to suppress the responses to mechanical stimuli, a Ricatti equation was solved and an admissible control law was derived. The approach presented here can be implemented in any biological process, and it would be useful to develop a transcription-mediated strategy for gene therapies and tissue engineering.
Sponsorship	IEEE Comput. Soc. Inf. Technol. Res. Inst. at Wright State Univ. IEEE Neural Networks Soc
Starting Page	313
Ending Page	318
File Size	652090
Page Count	6
File Format	PDF
ISBN	0769519075
DOI	10.1109/BIBE.2003.1188968
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2003-03-12
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Gene expression Optimal control Biological system modeling Probes Genomics Bioinformatics Data mining DNA Sequences Stress
Content Type	Text
Resource Type	Article

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