NDLI: Dopamine effects on infant pulmonary and systemic vasculature

Content Provider	IEEE Xplore Digital Library
Author	Ha, B. Roper, J.T. Mallett, H. Ferreiro, J.I. Lucas, C.L. Henry, G.W.
Copyright Year	1988
Description	Author affiliation: Dept. of Pediatrics & Surgery, North Carolina Univ., Chapel Hill, NC, USA (Ha, B.; Roper, J.T.; Mallett, H.; Ferreiro, J.I.; Lucas, C.L.; Henry, G.W.)
Abstract	The effects of dopamine on pulmonary and systematic vascular beds were investigated in 8 anesthetized goats (mean age 5+or-1 weeks). Pulmonary artery, aortic, left atrial, and central venous pressures and pulmonary and aortic flows were recorded simultaneously during a 10-minute baseline period and while infusion dopamine at 5, 10, 20, 40 160, and 320 mu g/kg/min. Pulmonary vascular resistance increased significantly at the 20 and 40 mu /kg/min infusion rates, while systemic vascular resistance decreased significantly at these rates. Characteristic impedances indicate generally increased trends. The pulmonary global reflection index indicates increased impedance mismatch at the high infusion rates, while the opposite is true for the systemic reflection index. Right heart work and the energy costs of transporting 1 cm/sup 3/ blood exceed systemic work and energy costs at the high rates of increase the resting tone of the pulmonary vascular bed, while the effect on systemic vascular tone remains unclear. The finding that the work and energy requirements of the heart are substantially increased at the higher infusion rates could affect the therapeutic value of dopamine use at these rates.<>
Starting Page	215
Ending Page	218
File Size	307107
Page Count	4
File Format	PDF
DOI	10.1109/NEBC.1988.19388
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1988-03-10
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Catheters Pediatrics Arteries Impedance Blood Immune system Heart rate Hemodynamics Electromagnetic measurements Surgery
Content Type	Text
Resource Type	Article

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