NDLI: Comparison of whole-brain to region-based fMRI analyses

Content Provider	IEEE Xplore Digital Library
Author	Saigal, R. Alkan, Y. Biswal, B.B. Alvarez, T.L.
Copyright Year	2012
Description	Author affiliation: Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ (Saigal, R.; Alkan, Y.; Alvarez, T.L.) \|\| Department of Radiology, University of Medicine and Dentistry New Jersey, Newark, NJ (Biswal, B.B.)
Abstract	Conventional fMRI analyses primarily utilize a general linear model composed of a single reference vector for the whole-brain. A single reference vector assumes the hemodynamic response is homogenous between different individuals and regions of interest. This study sought to determine whether a regional-based analysis that accounts for individual and regional differences would yield more sensitive results in terms spatial extent. Fifteen subjects without neurological dysfunction were scanned in a 3T MRI using an experimental block design of visual fixation compared to randomized vergence eye movements. Two temporal independent component analyses were conducted on individual subject data sets. The first used the data set composed of all the voxels within the brain while the second used the data from a masked region to isolate the voxels within the frontal eye fields, a critical cortical region needed to evoke vergence eye movements. A hierarchical temporal independent component analysis was used to compute group-level results. Spatial maps were compared. The regional based analysis resulted in fewer clusters which had greater spatial extent compared to the whole-brain analysis which had more dispersion within the functional activity. This technique has the potential to study individual regions while accounting for the variability of the natural heterogeneous nature of the hemodynamic response found in fMRI data.
Starting Page	347
Ending Page	348
File Size	145300
Page Count	2
File Format	PDF
ISBN	9781467311410
ISSN	21607001
e-ISBN	9781467311427
DOI	10.1109/NEBC.2012.6207107
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-03-16
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Vectors Visualization Magnetic resonance imaging Independent component analysis Light emitting diodes Hemodynamics Analytical models
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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