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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Pascu, E.I. Prescott, T. Stokes, J. |
| Copyright Year | 2009 |
| Description | Author affiliation: Materials Processing Research Center (MPRC), Dublin City University, Ireland (Pascu, E.I.; Prescott, T.; Stokes, J.) |
| Abstract | The present work examines porous scaffolds preparation methods by combining salt leaching, gas forming, solvent evaporation and phase separation techniques. The scaffolds are intended for bone tissue regeneration. It aims to combine the biodegradability of poly (ε- caprolactone) (PCL) with the osteoconductive properties of hydroxylapatite (HA) in order to create a composite which acts as a temporary support for bone cell attachment, growth and differentiation. Samples of different ceramic content were obtained. Scanning electron microscopy (SEM)/EDX), mechanical, hydrophylycity and degradation tests were carried out to characterize the composite. The prepared scaffolds have relatively homogenous pore structure throughout the matrix and the porosity was controlled by altering the initial volume fraction of salt particles and the amount of gas forming agents. The tensile strength of the HA/PCL composites decreased with increasing HA content, porosity and the technique being used. Future studies include bioactivity “in vitro” tests (samples will be immersed in simulated body fluid-SBF- solution for 30days at 37°C) and cell culturing. |
| Starting Page | 1 |
| Ending Page | 2 |
| File Size | 1036512 |
| Page Count | 2 |
| File Format | |
| ISBN | 9781424443628 |
| DOI | 10.1109/NEBC.2009.4967829 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2009-04-03 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Tissue engineering Scanning electron microscopy Testing Leaching Solvents Bone tissue Regeneration engineering Biodegradation Ceramics Degradation |
| Content Type | Text |
| Resource Type | Article |
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