NDLI: A Novel Approach Using Time–Frequency Analysis of Pulse-Oximeter Data to Detect Progressive Hypovolemia in Spontaneously Breathing Healthy Subjects

Content Provider	IEEE Xplore Digital Library
Author	Selvaraj, N. Shelley, K.H. Silverman, D.G. Stachenfeld, N. Galante, N. Florian, J.P. Mendelson, Y. Chon, K.H.
Copyright Year	1964
Abstract	Accurate and early detection of blood volume loss would greatly improve intraoperative and trauma care. This study has attempted to determine early diagnostic and quantitative markers for blood volume loss by analyzing photoplethysmogram (PPG) data from ear, finger, and forehead sites with our high-resolution time-frequency spectral (TFS) technique in spontaneously breathing healthy subjects (n=11) subjected to lower body negative pressure (LBNP). The instantaneous amplitude modulations (AM) present in heart rate (AM_HR) and breathing rate (AM_BR) band frequencies of PPG signals were calculated from the high-resolution TFS. Results suggested that the changes (P <; 0.05) in AM_BR and especially in AM_HR values can be used to detect the blood volume loss at an early stage of 20% LBNP tolerance when compared to the baseline values. The mean percent decrease in AM_HR values at 100% LBNP tolerance was 78.3%, 72.5%, and 33.9% for ear, finger, and forehead PPG signals, respectively. The mean percent increase in AM_BR values at 100% LBNP tolerance was 99.4% and 19.6% for ear and finger sites, respectively; AM_BR values were not attainable for forehead PPG signal. Even without baseline AM_HR values, our results suggest that hypovolemia detection is possible with specificity and sensitivity greater than 90% for the ear and forehead locations when LBNP tolerance is 100%. Therefore, the TFS analysis of noninvasive PPG waveforms is promising for early diagnosis and quantification of hypovolemia at levels not identified by vital signs in spontaneously breathing subjects.
Sponsorship	IEEE Engineering in Medicine and Biology Society
Page Count	8
File Size	780826
Starting Page	2272
Ending Page	2279
File Format	PDF
ISSN	00189294
Volume Number	58
Issue Number	8
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Blood Ear Fingers Forehead Heart rate Protocols Frequency modulation trauma care Blood loss hypovolemia lower body negative pressure (LBNP) photoplethysmogram (PPG) pulse oximeter time–frequency analysis
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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