NDLI: Point-of-Care Device for Quantification of Bilirubin in Skin Tissue

Content Provider	IEEE Xplore Digital Library
Author	Alla, S.K. Huddle, A. Butler, J.D. Bowman, P.S. Clark, J.F. Beyette, F.R.
Copyright Year	1964
Abstract	Steady state diffuse reflectance spectroscopy is a nondestructive method for obtaining biochemical and physiological information from skin tissue. In medical conditions such as neonatal jaundice excess bilirubin in the blood stream diffuses into the surrounding tissue leading to a yellowing of the skin. Diffuse reflectance measurement of the skin tissue can provide real time assessment of the progression of a disease or a medical condition. Here we present a noninvasive point-of-care system that utilizes diffuse reflectance spectroscopy to quantifying bilirubin from skin reflectance spectra. The device consists of an optical system integrated with a signal processing algorithm. The device is then used as a platform to study two different spectral databases. The first spectral database is a jaundice animal model in which the jaundice reflectance spectra are synthesized from normal skin. The second spectral database is the spectral measurements collected on human volunteers to quantify the different chromophores and other physical properties of the tissue such as Hematocrit, Hemoglobin, etc. The initial trials from each of these spectral databases have laid the foundation to verify the performance of this bilirubin quantification device.
Sponsorship	IEEE Engineering in Medicine and Biology Society
Page Count	4
File Size	315906
Starting Page	777
Ending Page	780
File Format	PDF
ISSN	00189294
Volume Number	58
Issue Number	3
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-03-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Skin Reflectivity Signal processing algorithms Analytical models Blood Humans Optical reflection skin reflectance Bilirubin quantification hyperbilirubinemia Jaundice
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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