NDLI: Calculation of the Best Basal–Bolus Combination for Postprandial Glucose Control in Insulin Pump Therapy

Content Provider	IEEE Xplore Digital Library
Author	Revert, A. Calm, R. Vehi, J. Bondia, J.
Copyright Year	1964
Abstract	Intensive insulin therapy in type 1 diabetes is based on the well-established practice of adjusting basal and bolus insulin independently. Basal insulin delivery is designed to optimize glucose concentrations between meals and overnight, while bolus insulin delivery is designed to optimize postprandial glucose concentrations. However, this strategy shows some limitations in the postprandial glucose control, especially for meals with high carbohydrate content. Strategies based on coordinating basal and bolus insulin in the postprandial period help in overcoming these limitations. An algorithm, based on mathematically guaranteed techniques (interval analysis), is presented in this paper. It determines, given the current glycemic state of the patient and the meal to be ingested, a basal-bolus combination that will yield a tight postprandial glycemic control according to the International Diabetes Federation guidelines. For a given meal, the algorithm reveals which bolus administration mode will enable a good postprandial performance: standard, square-wave, dual-wave, or temporal basal decrement. The algorithm is validated through an in silico study using the 30 subjects in the educational version of the Food and Drug Administration accepted University of Virginia simulator.
Sponsorship	IEEE Engineering in Medicine and Biology Society
Page Count	8
File Size	721464
Starting Page	274
Ending Page	281
File Format	PDF
ISSN	00189294
Volume Number	58
Issue Number	2
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-02-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Sugar Insulin Medical treatment Diabetes Design optimization Bonding Algorithm design and analysis Guidelines Blood Permission type 1 diabetes Insulin pump therapy interval analysis optimal experiment design (OED) postprandial glucose control set inversion
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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