NDLI: Reusable Ultrasonic Tissue Mimicking Hydrogels Containing Nonionic Surface-Active Agents for Visualizing Thermal Lesions

Content Provider	IEEE Xplore Digital Library
Author	Seong Keun Park Anjaneya Reddy Guntur, S.R. Kang Il Lee Dong-Guk Paeng Min Joo Choi
Copyright Year	1964
Abstract	The present study aims to identify a new recipe for reusable tissue mimicking phantoms that allows the optical visualization of thermal lesions produced in various applications of therapeutic ultrasound where thermal mechanisms are important. The phantom was made of polyacrylamide hydrogel containing a nonionic surface-active agent (NiSAA) as a temperature-sensitive indicator. Threshold temperature above which a thermal lesion is regarded to be formed in the phantom is controlled by selecting an NiSAA. In the present study, three NiSAAs of polyoxyethylene alkyl ether series with nominal clouding points of 66°C, 70°C, and 80°C were chosen. Test phantoms were prepared with polyacrylamide hydrogel, corn syrup and NiSAAs [5% (w/v)]. Key acoustic properties of the three NiSAA hydrogels were found to be similar to those of human liver. The phantoms were optically transparent at room temperature (25°C) and became opaque after exceeding the clouding points. The transparency was recovered on cooling, although the system demonstrated hysteresis. The phantoms were tested both in their ability to provide visualization of thermal lesions produced by high-intensity focused ultrasound and also to examine any characteristic differences in the shape of the lesions formed at different threshold temperatures. The present study suggests that the NiSAA polyacrylamide hydrogel will be of a practical use in quality assurance in various applications of therapeutic ultrasound where thermal mechanisms are important.
Sponsorship	IEEE Engineering in Medicine and Biology Society
Page Count	9
File Size	752202
Starting Page	194
Ending Page	202
File Format	PDF
ISSN	00189294
Volume Number	57
Issue Number	1
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Visualization Lesions Imaging phantoms Ultrasonic imaging Acoustic testing Temperature control Humans Liver Cooling Hysteresis visualization High-intensity focused ultrasound (HIFU) nonionic surface-active agent (NiSAA) polyacrylamide hydrogel thermal lesion tissue mimicking phantom
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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