NDLI: Mechanical Properties of the Respiratory System Derived From Morphologic Insight

Content Provider	IEEE Xplore Digital Library
Author	Ionescu, C.M. Segers, P. De Keyser, R.
Copyright Year	1964
Abstract	This paper aims to provide the mechanical parameters of the respiratory airways (resistance, inertance, and compliance) from morphological insight, in order to facilitate the correlations of fractional-order models with pathologic changes. The approach consists of taking into account wall thickness, inner radius, tube length, and tissue structure for each airway level to combine them into a set of equations for modeling the pressure drop, flow, wall elasticity, and air velocity (axial and radial). Effects of pulmonary disease affecting the inner radius and elastic modulus of bronchial tree are discussed. A brief comparison with the circulatory system, which poses similarities with the respiratory system, is also given. The derived mechanical parameters can serve as elements in a transmission line equivalent, whose structure preserves the geometry of the human respiratory tree. The mechanical parameters derived in this paper offer the possibility to evaluate input impedance by altering the morphological parameters in relation to the pulmonary disease. In this way, we obtain a simple, yet accurate, model to simulate and understand specific effects in respiratory diseases; e.g., airway remodeling. The final scope of the research is to relate the variations in airway structure with disease to the values of fractional-order model parameters.
Sponsorship	IEEE Engineering in Medicine and Biology Society
Page Count	11
File Size	555212
Starting Page	949
Ending Page	959
File Format	PDF
ISSN	00189294
Volume Number	56
Issue Number	4
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-04-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Mechanical factors Respiratory system Diseases Immune system Equations Elasticity Circulatory system Transmission lines Geometry Humans respiratory system Airways electrical transmission lines fractals input impedance mechanical properties modeling morphology Navier–Stokes
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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