NDLI: Advances in Giant Magnetoresistance Biosensors With Magnetic Nanoparticle Tags: Review and Outlook

Content Provider	IEEE Xplore Digital Library
Author	Wang, S.X. Guanxiong Li
Copyright Year	1965
Abstract	We present a review of giant magnetoresistance (GMR) spin valve sensors designed for detection of magnetic nanoparticles as biomolecular labels (nanotags) in magneto-nano biodetection technology. We discuss the intricacy of magneto-nano biosensor design and show that as few as approximately 14 monodisperse 16-nm superparamagnetic nanoparticles can be detected by submicron spin valve sensors at room temperature without resorting to lock-in (narrow band) detection. GMR biosensors and biochips have been successfully applied to the detection of biological events in the form of both protein and DNA assays with great speed, sensitivity, selectivity, and economy. The limit of molecular detection is well below 10 pM in concentration, and the protein or DNA assay time can be under two hours. The technology is highly scalable to deep multiplex detection of biomarkers in a complex disease, and amenable to integration of microfluidics and CMOS electronics for portable applications. On-chip CMOS circuitry makes a sensor density of 0.1-1 million sensors per square centimeter feasible and affordable. The theoretical and experimental results thus far suggest that magneto-nano biochip-based GMR sensor arrays and nanotags hold great promise in biomedicine, particularly for point-of-care molecular diagnostics of cancer, infectious diseases, radiation injury, cardiac diseases, and other diseases.
Sponsorship	IEEE Magnetics Society
Starting Page	1687
Ending Page	1702
Page Count	16
File Size	2240476
File Format	PDF
ISSN	00189464
Volume Number	44
Issue Number	7
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-07-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Giant magnetoresistance Biosensors Magnetic sensors Nanobioscience Sensor arrays Cardiac disease Spin valves Nanoparticles Temperature sensors Proteins spin valve sensor Biomolecule detection GMR biosensor magnetic biochip magnetic nanoparticle
Content Type	Text
Resource Type	Article
Subject	Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering

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Advances in Giant Magnetoresistance Biosensors With Magnetic Nanoparticle Tags: Review and Outlook