NDLI: YinYang Dynamic Neurobiological Modeling and Diagnostic Analysis of Major Depressive and Bipolar Disorders

Content Provider	IEEE Xplore Digital Library
Author	Wen-Ran Zhang Pandurangi, A.K. Peace, K.E.
Copyright Year	1964
Abstract	Since millions suffer from major depressive and bipolar disorders, the modeling, characterization, classification, and diagnostic analysis of such mental disorders bear great significance in medical and pharmaceutical research. Yin Yang bipolar sets are introduced for neurobiological modeling and diagnostic analysis of such disorders. It is shown that bipolar sets and a bipolar dynamic modus ponens (BDMP) build a technological bridge from a linear, static, and closed world to a nonlinear, dynamic, and open world of equilibria, quasi-equilibria, or nonequilibria and provide a novel model for bipolar neurobiological diagnostic analysis with added rigor to the current standard. It is shown that bipolar inference can help in understanding both the classic manifestations and the counterintuitive symptoms of bipolar disorders with applications in clinical psychopharmacology. Mathematical and visual characterizations of core features of such disorders are presented. A unified diagnosis and outcome model of different treatments are presented for different types of bipolar disorders. The significance and novelty of this work is twofold: 1) it introduces YinYang into biomedicine for the understanding of certain neurobiological disorders and fosters a new standard model for clinical, therapeutic, and pharmacological research and applications; 2) it presents a mathematical basis for the characterization of mood regulation in individuals and/or a cohort of patients with applications in biomedical engineering and potential applications in nanotechnologies for integrated care of major depressive and bipolar disorders.
Sponsorship	IEEE Engineering in Medicine and Biology Society
Page Count	11
File Size	1223361
Starting Page	1729
Ending Page	1739
File Format	PDF
ISSN	00189294
Volume Number	54
Issue Number	10
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-10-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Medical diagnostic imaging Psychology Mathematical model Biomedical engineering Psychiatry Mental disorders Pharmaceutical technology Bridges Mood Pediatrics YinYang bipolar sets Bipolar diagnostic analysis bipolar neurobiological modeling clinical psychopharmacology mental depression and bipolar disorder
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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