NDLI: Acoustic Estimation of Thermal Distribution in the Vicinity of Femtosecond Laser-Induced Optical Breakdown

Content Provider	IEEE Xplore Digital Library
Author	Zohdy, M.J. Tse, C. Jing Yong Ye O'Donnell, M.
Copyright Year	1964
Abstract	Laser-induced optical breakdown (LIOB), or photodisruption, can generate individual microbubbles in tissues for biomedical applications. We have previously developed a co-localized high-frequency ultrasound system to detect and characterize these laser-induced microbubbles. Because ultrasound speed varies with temperature, this system can also be used to directly estimate thermal effects in the vicinity of photodisruption. In this study, individual bubbles (sizes 60-100 mum) were created at the bottom of a water tank using a 793-nm, 100-fs Ti:Sapphire laser pulsed at 250 kHz. During and after breakdown, pulse-echoes from the tank bottom in the region surrounding a bubble were recorded with a single-element 85-MHz ultrasonic transducer, and temperature-dependent pulse-echo displacements were calculated using phase-sensitive correlation tracking. These displacements were then fit to a finite-element heat transfer model to estimate the effective thermal distribution. Estimates were calculated for laser exposure times ranging from 6.25 to 312.5 ms (1600 to 78 000 laser pulses), at 1.5 and 4 J/cm² fluences. Results suggest a minimal temperature increase (<1deg C) within 100 mum of a bubble created with <1600 laser pulses at 1.5 J/cm² fluence. This implies that LIOB can be controlled to be thermally noninvasive in the bubble vicinity
Sponsorship	IEEE Engineering in Medicine and Biology Society
Page Count	9
File Size	1233039
Starting Page	2347
Ending Page	2355
File Format	PDF
ISSN	00189294
Volume Number	53
Issue Number	11
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrafast optics Electric breakdown Laser modes Optical pulses Biomedical optical imaging Ultrasonic imaging Temperature Biomedical acoustics Acoustic signal detection Ultrasonic transducers laser-induced breakdown Acoustic thermal estimation bioeffects bubbles femtosecond lasers high-frequency ultrasound
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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