NDLI: Electrochemotherapy: transition from laboratory to the clinic

Content Provider	IEEE Xplore Digital Library
Author	Garner, H. Hofmann, G.A. Dev, S.B. Nanda, G.S.
Copyright Year	1983
Abstract	Although electroporation in the past has mainly been used as a research tool, recent work has demonstrated its potential for clinical applications. Some of the areas explored include electrochemotherapy (ECT), which utilizes electroporation as a means for delivering chemotherapeutic agents directly into tumor cells, encapsulation of drugs or genes into cells for their use as carrier systems, transdermal delivery of drugs or genes, gene therapy, and delivery of drugs or genes with an electroporation catheter. This article discusses the principles of ECT as a method of treating cancer, the requirements and development of electronic and electromechanical hardware for ECT, and it presents data for both in-vivo animal studies and clinical applications, especially for subcutaneous tumors. It is concluded that ECT has shown promise in treating a variety of cancers in humans. The basic principles are reasonably well understood. A good start has been made in the development of the necessary hardware to generate and apply the needed electric fields. As the human genome project progresses in identifying gene-based diseases and their possible cures, the same hardware system used for ECT can also be used for electrogene therapy. As ECT-based therapy becomes more widely recognized, it will offer an additional treatment modality and increased hope for cancer patients.
Starting Page	124
Ending Page	132
Page Count	9
File Size	1652137
File Format	PDF
ISSN	07395175
Volume Number	15
Issue Number	6
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1996-11-01
Publisher Place	U.S.A.
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Laboratories Electrical capacitance tomography Drugs Cancer Hardware Medical treatment Humans Tumors Encapsulation Gene therapy
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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