NDLI: A Prototype Inverse Solution in One-Dimension to Find the Origin of Excitation, Strand Radius, Intracellular Resistivity, or Distance from the Surface

Content Provider	IEEE Xplore Digital Library
Author	Di Persio, Deborah A. Barr, Roger C.
Copyright Year	1964
Abstract	Can extracellular waveforms from a one-dimensional strand be used to find the site of origin of excitation (xs0), strand radius (a0), intracellular resistivity (Ri0), or distance of the electrodes from the strand (b0)? A computer simulation of a strand 11.8 mm long was used to examine this question. The Ebihara-Johnson equations were used to model the membrane's behavior. Extracellular waveforms simulated at two of 60 points along the strand were taken as "measurements." The inverse calculations had the objective of finding one or two of the variables xs0, a0, Ri0, or b0 with the others known. The solution procedure compared the "measured" waveforms to trial waveforms obtained by varying all unknown parameters through their physiological range. For example, waveforms from two electrodes separated by 5.6 mm were sufficient to determine xs0 within 200 ¿Im at an error level of 150 ¿V rms if the stimulus site lay along the strand between the electrodes, and a0, Ri0, and b0 were given. A major objective was a systematic exploration of the errors as a function of the values of the trial parameters. The error curves were frequently found to have several relative minima. In general, however, no combination of unknowns other than the correct one led to rms errors within experimental noise levels, a result in marked contrast to that of most other inverse calculations in electrocardiography.
Sponsorship	IEEE Engineering in Medicine and Biology Society
Page Count	11
File Size	3202578
Starting Page	681
Ending Page	691
File Format	PDF
ISSN	00189294
Volume Number	BME-34
Issue Number	9
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1987-09-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Prototypes Conductivity Electrodes Extracellular Computer simulation Equations Computational modeling Error correction Noise level Electrocardiography
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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