NDLI: 1D-3D Registration for Intra-Operative Nuclear Imaging in Radio-Guided Surgery

Content Provider	IEEE Xplore Digital Library
Author	Vetter, C. Lasser, T. Okur, A. Navab, N.
Copyright Year	1982
Abstract	3D functional nuclear imaging modalities like SPECT or PET provide valuable information, as small structures can be marked with radioactive tracers to be localized before surgery. This positional information is valuable during surgery as well, for example when locating potentially cancerous lymph nodes in the case of breast cancer. However, the volumetric information provided by pre-operative SPECT scans loses validity quickly due to posture changes and manipulation of the soft tissue during surgery. During the intervention, the surgeon has to rely on the acoustic feedback provided by handheld gamma-detectors in order to localize the marked structures. In this paper, we present a method that allows updating the pre-operative image with a very limited number of tracked readings. A previously acquired 3D functional volume serves as prior knowledge and a limited number of new 1D detector readings is used in order to update the prior knowledge. This update is performed by a 1D-3D registration algorithm that registers the volume to the detector readings. This enables the rapid update of the visual guidance provided to the surgeon during a radio-guided surgery without slowing down the surgical workflow. We evaluate the performance of this approach using Monte-Carlo simulations, phantom experiments and patient data, resulting in a positional error of less than 8 mm which is acceptable for surgery. The 1D-3D registration is also compared to a volumetric reconstruction using the tracked detector measurements without taking prior information into account, and achieves a comparable accuracy with significantly less measurements.
Sponsorship	IEEE Engineering in Medicine and Biology Society IEEE Nuclear and Plasma Sciences Society IEEE Signal Processing Society IEEE Ultrasonics, Ferroelectrics, and Frequency Control Society
Starting Page	608
Ending Page	617
Page Count	10
File Size	1106573
File Format	PDF
ISSN	02780062
Volume Number	34
Issue Number	2
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Lymph nodes Surgery Detectors Single photon emission computed tomography Visualization Phantoms Volume measurement single photon emission computed tomography Image reconstruction nuclear imaging registration
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering Computer Science Applications Radiological and Ultrasound Technology Software

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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