NDLI: A Distributed Amplifier System for Bilayer Lipid Membrane (BLM) Arrays With Noise and Individual Offset Cancellation

Content Provider	IEEE Xplore Digital Library
Author	Crescentini, M. Bennati, M. Saha, S. de Planque, M.R.R. Morgan, H. Tartagni, M.
Copyright Year	2007
Abstract	Lipid bilayer membrane (BLM) arrays are required for high throughput analysis, for example drug screening or advanced DNA sequencing. Complex microfluidic devices are being developed but these are restricted in terms of array size and structure or have integrated electronic sensing with limited noise performance. We present a compact and scalable multichannel electrophysiology platform based on a hybrid approach that combines integrated state-of-the-art microelectronics with low-cost disposable fluidics providing a platform for high-quality parallel single ion channel recording. Specifically, we have developed a new integrated circuit amplifier based on a novel noise cancellation scheme that eliminates flicker noise derived from devices under test and amplifiers. The system is demonstrated through the simultaneous recording of ion channel activity from eight bilayer membranes. The platform is scalable and could be extended to much larger array sizes, limited only by electronic data decimation and communication capabilities.
Sponsorship	IEEE Circuits and Systems Society IEEE Engineering in Medicine and Biology Society
Starting Page	334
Ending Page	344
Page Count	11
File Size	2036393
File Format	PDF
ISSN	19324545
Volume Number	9
Issue Number	3
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Noise CMOS integrated circuits Apertures Field programmable gate arrays Lipidomics Electrodes Universal Serial Bus sensor array Bilayer lipid membrane current amplifier discrete-time amplifier electrophysiology ion channel recording low noise microfluidic device parallel BLM recording
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering Biomedical Engineering

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