NDLI: Double Selection Based Semi-Supervised Clustering Ensemble for Tumor Clustering from Gene Expression Profiles

Content Provider	IEEE Xplore Digital Library
Author	Zhiwen Yu Hongsheng Chen You, J. Hau-San Wong Jiming Liu Le Li Guoqiang Han
Copyright Year	2004
Abstract	Tumor clustering is one of the important techniques for tumor discovery from cancer gene expression profiles, which is useful for the diagnosis and treatment of cancer. While different algorithms have been proposed for tumor clustering, few make use of the expert's knowledge to better the performance of tumor discovery. In this paper, we first view the expert's knowledge as constraints in the process of clustering, and propose a feature selection based semi-supervised cluster ensemble framework (FS-SSCE) for tumor clustering from bio-molecular data. Compared with traditional tumor clustering approaches, the proposed framework FS-SSCE is featured by two properties: (1) The adoption of feature selection techniques to dispel the effect of noisy genes. (2) The employment of the binate constraint based K-means algorithm to take into account the effect of experts' knowledge. Then, a double selection based semi-supervised cluster ensemble framework (DS-SSCE) which not only applies the feature selection technique to perform gene selection on the gene dimension, but also selects an optimal subset of representative clustering solutions in the ensemble and improve the performance of tumor clustering using the normalized cut algorithm. DS-SSCE also introduces a confidence factor into the process of constructing the consensus matrix by considering the prior knowledge of the data set. Finally, we design a modified double selection based semi-supervised cluster ensemble framework (MDS-SSCE) which adopts multiple clustering solution selection strategies and an aggregated solution selection function to choose an optimal subset of clustering solutions. The results in the experiments on cancer gene expression profiles show that (i) FS-SSCE, DS-SSCE and MDS-SSCE are suitable for performing tumor clustering from bio-molecular data. (ii) MDS-SSCE outperforms a number of state-of-the-art tumor clustering approaches on most of the data sets.
Sponsorship	IEEE Computer Society
Starting Page	727
Ending Page	740
Page Count	14
File Size	1161281
File Format	PDF
ISSN	15455963
Volume Number	11
Issue Number	4
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-07-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Cancer Tumors Gene expression Bioinformatics Clustering algorithms Algorithm design and analysis Mutual information gene expression profiles Cluster ensemble tumor clustering semi-supervised clustering feature selection
Content Type	Text
Resource Type	Article
Subject	Applied Mathematics Genetics Biotechnology

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2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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