NDLI: A Novel MRI Tracer-Based Method for Measuring Water Diffusion in the Extracellular Space of the Rat Brain (December2013)

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Guest Editorial: Computational Solutions to Large-Scale Data Management and Analysis in Translational and Personalized Medicine

Predictive Monitoring of Mobile Patients by Combining Clinical Observations With Data From Wearable Sensors

Identification of COPD Patients’ Health Status Using an Intelligent System in the CHRONIOUS Wearable Platform

Enabling Smart Personalized Healthcare: A Hybrid Mobile-Cloud Approach for ECG Telemonitoring

Augmenting Breath Regulation Using a Mobile Driven Virtual Reality Therapy Framework

A Joint FED Watermarking System Using Spatial Fusion for Verifying the Security Issues of Teleradiology

Removing Batch Effects From Histopathological Images for Enhanced Cancer Diagnosis

On the Identification of Circulating Tumor Cells in Breast Cancer

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Robust and Sensitive Video Motion Detection for Sleep Analysis

Temporal and Spatial Patterns of Gene Profiles during Chondrogenic Differentiation

Using Evolutional Properties of Gene Networks in Understanding Survival Prognosis of Glioblastoma

A Composite Framework for the Statistical Analysis of Epidemiological DNA Methylation Data with the Infinium Human Methylation 450K BeadChip

Web-Based Workflow Planning Platform Supporting the Design and Execution of Complex Multiscale Cancer Models

Modeling Biological Pathway Dynamics With Timed Automata

The Technologically Integrated Oncosimulator: Combining Multiscale Cancer Modeling With Information Technology in the In Silico Oncology Context

An Automated Screening System for Tuberculosis

A Bicluster-Based Bayesian Principal Component Analysis Method for Microarray Missing Value Estimation

On the Seamless, Harmonized Use of ISO/IEEE11073 and OpenEHR

Design of a RESTful Web Information System for Drug Prescription and Administration

Designing an Architecture for Monitoring Patients at Home: Ontologies and Web Services for Clinical and Technical Management Integration

A Computational Tool for Preoperative Breast Augmentation Planning in Aesthetic Plastic Surgery

Treatment Planning and Image Guidance for Radiofrequency Ablation of Large Tumors

Local Mesh Patterns Versus Local Binary Patterns: Biomedical Image Indexing and Retrieval

Non-Calcified Coronary Atherosclerotic Plaque Characterization by Dual Energy Computed Tomography

Computer-Aided Staging of Lymphoma Patients With FDG PET/CT Imaging Based on Textural Information

Efficient Acceleration of Mutual Information Computation for Nonrigid Registration Using CUDA

A Spatiotemporal-Based Scheme for Efficient Registration-Based Segmentation of Thoracic 4-D MRI

A Novel MRI Tracer-Based Method for Measuring Water Diffusion in the Extracellular Space of the Rat Brain (December2013)

Multiple Kernel Learning in the Primal for Multimodal Alzheimer’s Disease Classification

Red Blood Cell Tracking Using Optical Flow Methods

Automatic Handling of Tissue Microarray Cores in High-Dimensional Microscopy Images

Exploring Early Glaucoma and the Visual Field Test: Classification and Clustering Using Bayesian Networks

Context-driven, Prescription-Based Personal Activity Classification: Methodology, Architecture, and End-to-End Implementation

Accelerometry-Based Home Monitoring for Detection of Nocturnal Hypermotor Seizures Based on Novelty Detection

Walking-Age Analyzer for Healthcare Applications

sEMG-Based Joint Force Control for an Upper-Limb Power-Assist Exoskeleton Robot

Automated Detection of Perturbed Cardiac Physiology During Oral Food Allergen Challenge in Children

Quality of the Wireless Electrocardiogram Signal During Physical Exercise in Different Age Groups

Detection of Respiratory Arousals Using Photoplethysmography (PPG) Signal in Sleep Apnea Patients

Single-Trial EEG Classification Using Logistic Regression Based on Ensemble Synchronization

Compressed Sensing Technology-Based Spectral Estimation of Heart Rate Variability Using the Integral Pulse Frequency Modulation Model

Design and Evaluation of RFID Deployments in a Trauma Resuscitation Bay

Erratum to “An Effective Approach for Detection and Segmentation of Protein Spots on 2-D Gel Images” [Jan 14 67-76]

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Issue 2

Issue 1

Year : 2013 Volume : 17

A Novel MRI Tracer-Based Method for Measuring Water Diffusion in the Extracellular Space of the Rat Brain (December2013)

Content Provider	IEEE Xplore Digital Library
Author	Hongbin Han Chunyan Shi Yu Fu Long Zuo Kejia Lee Qingyuan He Haojun Han
Copyright Year	2013
Abstract	We proposed a novel MRI tracer-based method for the determination of water diffusion in the brain extracellular space (ECS). The measuring system was validated in 32 Sprague Dawley rats. The rats were randomly divided into four groups with different injection sites: 1) caudate nucleus (Cn.); 2) thalamus (T.); 3) cortex (Cor.); and 4) substantia nigra (Sn.). The spin-lattice relaxation time of hydrogen nuclei in water molecules were shortened, which presented as high signal on MRI after the injection of gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) into the rat brain ECS. The enhancement on MRI decreased over time due to the water diffusion and clearance process within the brain ECS. The process was dynamically recorded on a series of magnetic resonance (MR) images. As the increment in signal intensity (ΔSI) could be converted to local Gd-DTPA concentration, the water diffusion parameters were further calculated voxel by voxel based on a modified diffusion model. The most tortuous ECS (λ = 1.77 ± 0.71) was found in Sn. with DSn of (2.06 ± 1.01) × 10 ^-4mm ²·s ^-1 ( P <; 0.05). No statistical difference was demonstrated among DCn, D* T., and DCor. with an average D values of (3.28 ± 0.88) × 10^-4mm² ·s^-1( F = 0.18, P > 0.05). By using the tracer-based MRI method, the local diffusion parameters of the brain ECS can be quantitatively measured. The different distribution territories and clearance rates of the tracer in four brain areas indicated that the brain ECS is a physiologically partitioned system.
Page Count	6
File Size	1009429
Starting Page	978
Ending Page	983
File Format	PDF
ISSN	21682194
Volume Number	18
Issue Number	3
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Magnetic resonance imaging Biomedical measurement Educational institutions Brain Extracellular Probes Time measurement water diffusion Brain interstitial fluid extracellular space (ECS) gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) magnetic resonance imaging (MRI)
Content Type	Text
Resource Type	Article
Subject	Health Information Management Health Informatics Electrical and Electronic Engineering Computer Science Applications Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Stimulation Modeling on Three-Dimensional Anisotropic Diffusion of MRI Tracer in the Brain Interstitial Space

Imaging of endolymphatic and perilymphatic fluid at 3T after intratympanic administration of gadolinium-diethylene-triamine pentaacetic acid.

Factors predicting aggressiveness of non-hypervascular hepatic nodules detected on hepatobiliary phase of gadolinium ethoxybenzyl diethylene-triamine-pentaacetic-acid magnetic resonance imaging

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SYNTHESIS AND STUDY ON MAGNETIC RESONANCE IMAGING PERFORMANCE OF GD(III)-DTPA-BISBENZOTHIAZOL HYDRAZIDE

Gadolinium Ethoxybenzyl Diethylenetriamine Pentaacetic Acid (Gd-EOB-DTPA)-Enhanced Magnetic Resonance Imaging and Multidetector-Row Computed Tomography for the Diagnosis of Hepatocellular Carcinoma

A Novel MRI Tracer-Based Method for Measuring Water Diffusion in the Extracellular Space of the Rat Brain (December2013)

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A Novel MRI Tracer-Based Method for Measuring Water Diffusion in the Extracellular Space of the Rat Brain (December2013)